Biomarkers, or biological markers, are measurements reflecting a biological state. They generally refer to proteins or other cellular components which can be found in body fluids such as CSF, blood or urine, and whose levels specifically reflect a disease or injury.
Biomarkers can be detected by physical, biochemical, or molecular methods. They may be used alone or in combination as indicators of normal and pathogenic biological processes, or of pharmacological responses to a therapeutic intervention.
The development of biomarkers plays an important role in the diagnosis, management and treatment of a given disease. Biomarkers also represent precious tools for assessing the efficacy of potential therapeutic interventions in clinical trials.